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Molecular 'Chevaliers' Rattle The Darwin-faithful: Review Of The Fifth Chapter Of Signature In The Cell

Robert Deyes continues his chapter by chapter analysis of Signature in the Cell at www.uncommondescent.com.

Amidst the many memories that I cherish from my college undergraduate years are the get-togethers that friends and I would have to discuss the core textbook principles of molecular biology. Benjamin Lewin's Genes IV stands out as one of the treasured resources we would pour over as we searched for the facts on the makeup of life. Perhaps most often visited amongst our topics of discussion were those of eukaryotic transcription and translation principally because for all of us there was something deeply unsettling about the naturalistic foundations upon which the emergence of these processes had been presented. So unsettled were we that we could never quite swallow the evolutionary suppositions that accompanied the factual details.

To recapitulate on what we now know about transcription, eukaryotes are furnished with three different RNA polymerases differing primarily in the types of genes that they transcribe. Each RNA Polymerase binds to a class of DNA sequence known as a promoter from which transcription then begins (1). A number of proteins called transcription factors, upon which these polymerases are absolutely dependent, form a functional transcription 'apparatus'. RNA Polymerase II for example requires at least four transcription factors, TFIIA, TFIIB, TFIID and TFIIE for activity -- a fact that is self-evident in Stephen Meyer's pictorial outlines in the fifth chapter of his book Signature In The Cell

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